What's in a Name?: Heat Shock Protein 27 and Keratinocyte Differentiation
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چکیده
منابع مشابه
Hyperglycemia and antibody titres against heat shock protein 27 in traumatic brain injury patients on parenteral nutrition
Objective(s):Hyperglycemia worsens the neuronal death induced by cerebral ischemia. Previous studies demonstrated that diabetic hyperglycemia suppressed the expression of heat shock protein 70 and 60 (HSP70 and 60) in the liver. IgG antibody titres against heat shock protein 27 (anti HSP27) were measured to determine whether hyperglycemia exacerbates ischemic brain damage by suppressing the exp...
متن کاملShock Protein 27 Mutant Protects Against Ischemia/Reperfusion Injury in a Transgenic Overexpression of Wild-Type Heat Shock Protein 27 and a Nonphosphorylatable Heat
John M. Hollander, Jody L. Martin, Darrell D. Belke, Brian T. Scott, Eric Swanson, Vignesh Mouse Model Shock Protein 27 Mutant Protects Against Ischemia/Reperfusion Injury in a Transgenic Overexpression of Wild-Type Heat Shock Protein 27 and a Nonphosphorylatable Heat Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2004 American Heart Association, Inc. All rights reserved. is publishe...
متن کاملReductive stress: linking heat shock protein 27, glutathione, and cardiomyopathy?
Normal cellular functions essentially depend on a balanced redox environment. Free radicals and nonradical oxidants can shift the redox balance toward a more “oxidized” state, which is counteracted by the intracellular antioxidant defense systems. These include the enzymes superoxide dismutase and catalase, as well as the thiol-reducing systems (glutathione, glutaredoxin, and thioredoxin). Glut...
متن کاملOverexpression of wild-type heat shock protein 27 and a nonphosphorylatable heat shock protein 27 mutant protects against ischemia/reperfusion injury in a transgenic mouse model.
BACKGROUND The small heat shock protein 27 (hsp27) increases in expression with ischemia/reperfusion (I/R) insult in the heart. One feature of the small hsps is their ability to oligomerize and form intracellular aggregates. Oligomerization pattern is governed by the phosphorylation state of the protein that may influence their ability to protect against cellular stresses. METHODS AND RESULTS...
متن کاملRetinal preconditioning and the induction of heat-shock protein 27.
PURPOSE Brief periods of ischemia have been shown to protect the retina from potentially damaging periods of ischemia. This phenomenon has been termed ischemic preconditioning or ischemic tolerance. In the present study the cellular changes in levels of heat shock protein (Hsp)27, -70, and -90 mRNA and expression of Hsp in the rat retina associated with ischemic preconditioning were evaluated. ...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2010
ISSN: 0022-202X
DOI: 10.1038/jid.2009.330